Virgin Trains introduced the 53 Alstom built Class 390 Pendolinos to the West Coast Main Line in 2002 and these 9 and 11 car 25kV EMUs soon dominated Inter City services on the route. At the end of 2019, the class 390s passed to Avanti West Coast, the new franchisee, and remain on WCML services.
- Class 320, 321, 322
- Class 421 4-CIG
- Class 442
- Class 423 4-VEP
- Class 156
- Class 180
- Class 707
- Class 150
- Class 350
- Class 325
- Class 185
- Class 319, 769
- Class 375, 377, 379, 387
- Class 397
- Class 345
- Class 491 4TC
- Class 165, 166
- Class 158, 159
- Class 701
- Class 168 & 170-172
- Class 800 - 810
- Class 458
- Class 455, 456
- Class 220, 221, 222
- Class 444, 450